Background We report a case of prolonged exercise-induced rhabdomyolysis (ER) in an otherwise healthy male malignant hyperthermia susceptible (MHS) individual. Case report A 42-year old healthy Caucasian male contacted our malignant hyperthermia (MH) hotline due to cramps and muscle pain one week after moderate exercise. He was already diagnosed MHS in 1988 by in vitro contracture test (IVCT)， after a suspected MH episode during general anaesthesia. At present， he reported severe muscle pain and cramps in both upper legs. The discomfort has started after moderate endurance training with mild muscle soreness for 2 days. On the 3 rd day， pain increased， accompanied by severe muscle cramps in both upper legs. Symptoms were worsened by cold temperature. Due to pain， muscle weakness and swelling in both upper legs， he had sought medical attention on day 5 in a surgical outpatient clinic， where an ultrasound examination showed a “homogenous increase in muscle density of both quadriceps muscles”. ...
Alfred Sommer， MD， MHS， is dean emeritus of the Johns Hopkins Bloomberg School of Public Health and University Distinguished Service Professor of Ophthalmology， Epidemiology， and International Health. He is a member of the National Academy of Sciences and the Institute of Medicine and serves as the chair of the board of the Albert and Mary Lasker Foundation.
Does family history of depression predict major depression in midlife women? Study of Women’s Health Across the Nation Mental Health Study (SWAN MHS)
This study aims to determine whether family history of depression predicts major depression in midlife women independent of psychosocial and health profiles at midlife. Participants were 303 African American and Caucasian women (42-52 years at baseline) recruited into the Study of Women's Health Across the Nation (SWAN) and the Women's Mental Health Study (MHS) in Pittsburgh. Major depression was assessed annually with the Structured Clinical Interview for DSM-IV. Family mental health history was collected at the ninth or tenth follow-up. Multivariable logistic regression was used to determine whether family history of depression predicted major depression in midlife， adjusting for covariates. The odds of experiencing major depression during the study were three times greater for those with a family history than for those without a family history (OR = 3.22， 95% CI = 1.95-5.31). Family history predicted depression (OR = 2.67， 95% CI = 1.50-4.78) after adjusting for lifetime history of depression， age， trait anxiety， chronic medical conditions， and stressful life events. In analyses stratified by lifetime history of depression， family history significantly predicted depression only among women with a lifetime history of depression. Family history of depression predicts major depression in midlife women generally， but particularly in those with a lifetime history of depression prior to midlife.
Psychiatric disorders are associated with an increased risk of injuries: data from the Iranian Mental Health Survey (Iran MHS).
Background： Injuries and psychiatric disorders， notably both major public health concerns， are associated with a high burden and are believed to be bi-directionally correlated. Those inflicted with injuries face increased risks of mental illnesses. Psychiatric disorders may make the individual prone to injuries. The objective of the study was to assess the correlation of mental disorders with n...
Abstract Top of page Abstract Introduction Methods Results Discussion Conflict of Interests References Clinical guidelines of the European Society of Gastrointestinal Endoscopy recommend the insertion of self-expandable metallic stents (SEMS) as opposed to plastic stents (PS) in patients with unresectable malignant perihilar stricture (MHS). However， PS are cheaper and easier to insert into the biliary duct compared to SEMS. Furthermore， PS are removable and easy to move into subsequent drainage procedures. We conducted the present retrospective single-center study to elucidate the predictive factors associated with stent patency period duration in patients with unresectable MHS who would benefit from a long patency period after PS placement. This study included 56 consecutive patients with unresectable MHS who were drained using PS. PS failure occurred in 26 (46.4%) patients. The median patency period was72 days (95% confidence interval： 29.8–114). The only significant predictive factor associated with the length of the stent patency period was history of previous endoscopic sphincterotomy (EST). Median patency periods with and without previous EST were 28 and 109 days， respectively ( P = 0.016). In conclusion， we suggest that conventional biliary drainage with PS is still a suitable option for the treatment of unresectable MHS in patients without previous EST.
With almost 150，000 deaths every year in France (26 times more than on the roads)， cancers represent the second cause of mortality after cardiovascular disease. In 2002， 10 million new cases of cancer were registered in the world and there were 6 million deaths (of which 40% in developed countries). Moreover， the World Health Organisation (WHO) predicts a significant increase in the number of new cases between now and 2020 (+40% in developed countries and +100% in developing countries)， due mainly to longer life expectations， change in behaviour， and degradation of the environment. The word ‘cancer’ is a generic term covering a group of more than a hundred diseases， all characterised by the organism losing control over the proliferation of certain cells. These cells then develop in an anarchic way， eventually constituting a tumour which invades surrounding tissue and in many cases ends up disseminating to distant tissues (metastases).
Abstract BACKGROUND： This article presents data on the psychometric properties of a new measure， the Adolescent Quality of Life Mental Health Scale (AQOL-MHS)， designed to measure quality of life in clinical samples of Latino adolescents aged 12-18 years. Participants were recruited in Puerto Rico to have one of five prevalent mental health disorders. The initial instrument development was achieved through a grounded theory approach with the use of focus groups and in-depth interviews. METHODS： We conducted two stages of exploratory factor analyses (EFA) on 60 candidate items. The first stage was to establish the number of factors to extract， and the second was to improve the model by selecting the best items. A final EFA model retained 31 items and 3 factors labeled Emotional Regulation (11 items)， Self-Concept (10 items) and Social Context (10 items). RESULTS： The instrument showed good internal consistency， test-retest reliability， and construct validity. The hypotheses-driven validity tests were all supportive of the AQOL-MHS. There was evidence for convergent validity and discriminant validity， and results for known-groups' validity were overwhelmingly supportive of the ability of the instrument to identify differences between groups. CONCLUSIONS： These preliminary findings support our conceptual model and the use of the AQOL-MHS domain and overall scores. We believe that this instrument will provide clinicians additional insight into the different aspects of quality of life that are important to adolescents with mental health problems. Therefore， we consider the AQOL-MHS a vital patient-centered outcome measure for assessment strategies in the prevention and treatment of this population.