DTU I isolates of Trypanosoma cruzi induce upregulation of Galectin-3 in murine myocarditis and fibrosis
Chagas is a major public concern since 30% of infected patients develop cardiac alterations. The relationship between discrete typing units (DTUs) and the biological properties exhibited by the parasite population has yet to be elucidated. In this study， we analysed the expression of α-smooth muscle (α-SMA) and () associated with cardiac () remodelling a chronic induced by Tc I genotypes. We found the induction of was associated with the upregulation of Col I， α-SMA， ， -γ and ， as analysed by q-PCR. In myocardial areas of fibrosis， the intensity of and significant remodelling correlated with the presence of Col I-， - and α-SMA-positive . These results are promising for the further efforts to evaluate the relevance of in Chagas ， since this was proposed as a prognosis marker in patients.