CiteSeerX - Scientific documents that cite the following paper： Mico Loretan. "Pitfalls in Tests for Changes in Correlations
CiteSeerX - Scientific documents that cite the following paper： The Rise of "The Rest"： Challenges to the West from Late-Industrializating Economies
Developmental toxicity and endocrine disruption of naphthenic acids on the early life stage of zebrafish ( Danio rerio )
Abstract Oil sands process-affected water (OSPW) has been reported to exhibit adverse effects on the environment and wildlife. Although the compounds responsible are unknown， naphthenic acids (NAs) have been considered to be implicated. The current study was designed to investigate whether NAs might cause developmental toxicity and endocrine disruption on the early life stage of zebrafish ( Danio rerio ). The success of embryo hatch was inhibited by 2.5 mg l –1 oil sands NAs (OS-NAs) exposure， and both OSPW NAs and commercial NAs (C-NAs) exposure resulted in a variety of developmental lesions in the fish larvae， such as yolk sac edema， pericardial edema and spinal malformation. The transcription of genes involved cytochrome P450 aromatase (CYP19a and CYP19b)， estrogen receptors (ERα， ERβ1 and ERβ2)， and vitellogenin (VTG) was analyzed to evaluate the endocrine disrupting effects of NAs. Significant up-regulated gene expressions of CYP19b， ERα and VTG were observed in both OS-NAs and C-NAs groups， which indicated the deleteriously estrogenic potential of NAs. These results confirmed that NAs derived from crude petroleum could negatively impact the development and endocrine function of zebrafish， and be primarily responsible for the toxicity of OSPW. Copyright © 2015 John Wiley & Sons， Ltd.
CiteSeerX - Scientific documents that cite the following paper： Marichev： "Integrals and series. Elementary functions
CiteSeerX - Scientific documents that cite the following paper： et al.， "Designing Empathic Agents： Adults vs. Kids，" presented at ITS 2004
Assay of vtg, ERs and PPARs as endpoint for the rapid in vitro screening of the harmful effect of Di-(2-ethylhexyl)-phthalate (DEHP) and phthalic acid (PA) in zebrafish primary hepatocyte cultures
In the last years the concern about the negative effects of phthalates on reproduction significantly increased. Considering that， at date data available dealing with the adverse outcome of Di-(2-ethylhexyl)-phthalate (DEHP) on the reproduction of several species are still contrasting， in this study， the effects induced by DEHP (0.05， 0.1， 1， 10 and 100 nM) and its active metabolite， phthalic acid (PA) (0.01， 0.1， 1 and 10 μM)， were analyzed in zebrafish， Danio rerio， primary hepatocyte cultures， using target molecules involved in fish reproduction (vitellogenin--vtg and estrogen receptors--ERα， β1 and β2) and metabolism (peroxisome proliferators activated receptors--PPAR α， β， γ). The use of in vitro culture， in fact， has the potential to significantly reduce the number of animals sacrificed for research allowing a precise control of the physical and chemical parameters that is often not possible in vivo. Moreover， since many toxicological studies revealed a sex specific response to toxicants， male and female primary hepatocyte cultures were set up to elucidate the possible gender specific effects of two common environmental phthalates. The increase of vtg levels observed in the culture media of male or female hepatocytes strongly evidenced the phthalates E2-like action. Moreover， the data obtained suggested that the observed different ERs isoforms modulation is otherwise associated with the vtg increase， depending on fish gender. Regarding PPARs， a similar trend of expression was found in both males and females. In conclusion， this study enforces the role of vtg as biomarker for evaluate the presence of environmental doses of DEHP and PA. Considering the similar gender modulation observed for vtg and PPARs， these molecules could be used for the rapid screening of the presence of DEHP and PA. Noteworthy the gender specific modulation observed for ERs opens a debate on the estrogenic mechanism of action of DEHP and PA and their role on vtg induction.
Designer tools for hypertext authoring," IEE Colloquium on "The Authoring and Application of Hypermedia-Based User Interfaces," Digest No: 95/202
CiteSeerX - Scientific documents that cite the following paper： Designer tools for hypertext authoring，" IEE Colloquium on "The Authoring and Application of Hypermedia-Based User Interfaces，" Digest No： 95/202
Is the physician an "easy mark"?
CiteSeerX - Scientific documents that cite the following paper： 2000) "Dynamic Voluntary Contribution to a Public Project
CiteSeerX - Scientific documents that cite the following paper： et al， "Neuroanatomy of Rett Syndrome： a volumetric imaging study