Juvenile temporal arteritis (JTA) is a nongranulomatous inflammation of the temporal artery with fragmentation of the internal elastic lamina and no concurrent systemic manifestations. It is a rare clinicopathologic entity with fewer than 20 reported cases， most of which represent localized disease with no recurrence or systemic symptoms at follow-up of up to 2 years. Histopathologic features can include lymphoeosinophilic infiltrate and endothelial proliferation. As the histology may resemble angiolymphoid hyperplasia with eosinophilia or Kimura disease， whether JTA is a discrete localized disease or a manifestation of these systemic conditions has been debated. We present a case of a 36-year-old Jamaican woman with a painful forehead nodule that showed histologic features of JTA， including intimal hyperplasia， lymphoeosinophilic inflammation of the vessel wall， and disruption of the internal elastic lamina; distinctive signet ringlike cytomorphologic alterations of the endothelial cells were noted as well. The lesion also showed extensive subcutaneous lymphoeosinophilic infiltrates and neovascularization with extension into the underlying muscle consistent with angiolymphoid hyperplasia with eosinophilia or Kimura disease. As the connection between JTA and angiolymphoid hyperplasia with eosinophilia and Kimura disease is currently debated and most reported cases of JTA have had only brief follow-up， the long-term sequelae of JTA are not known and careful patient monitoring may be necessary.
目的 探讨苏州吴江黎里地区人群肺结核调查延诊的预防分析.方法 以人口比较集中的街区为单位，2005年，2006年，2007年，2008年，2009年和2010年分别调查了2，801人，2，932 人，2，876人，2，846人，1，998人和2，188人合计15，641人.结果 在调查的15，641人中发现125例新发肺结核病人，主动发现45例，占36.0%;被动发现52例，占41.6%，病人延诊16例占12.8%和医师 延诊12例占9.6%，以被动发现为主.结论 以预防宣教为先，认真做好胸部X线片和痰涂工作是肺结核早发现、早干预和早治疗的有效措施.
The article unveils the plan of the JTA Travel Group to work with technology firm GoQuo to introduce a new dynamic packaging and distribution technology. The technology will include hotel and flight booking engines. JTA Travel hopes that such technology will allow faster and more flexible searching， and offer better service for customers.
摘 要： 乙型病毒性肝炎（乙肝）报告发病率多年来位居传染病前列，其流行范围广，危害重，已成为重大的公共卫生问题之一。为此，我们调查了2006年～2009年3 216名接种乙肝疫苗人群HBsAg和抗-HBs水平。
JTA-009, a fully human antibody against human AILIM/ICOS, ameliorates graft-vs-host reaction in SCID mice grafted with human PBMCs.
OBJECTIVE： Activation-inducible lymphocyte immunomediatory molecule (AILIM; also referred to as inducible costimulator [ICOS]) is the third molecule identified in the CD28 family participating in T-cell activation. AILIM/ICOS has been implicated in both effector and pathogenic T-cell functions， as evidenced by the beneficial effects of AILIM/ICOS blockade in several murine disease models. In the present study， the role of human AILIM/ICOS in T-cell function was investigated using a fully human monoclonal antibody specific to human AILIM/ICOS (JTA-009). MATERIALS AND METHODS： The effect of JTA-009 on allogenic T-cell proliferation was examined using human mixed lymphocyte reaction (MLR). To investigate the efficacy of AILIM/ICOS blockade in vivo， a graft-vs-host disease (GVHD) model， in which severe combined immunodeficient (SCID) mice were grafted with human peripheral blood mononuclear cells (PBMCs)， was used. RESULTS： In MLR， suppressive effect of JTA-009 on allogenic T-cell proliferation was detected with comparable potency to CD28 blockade by cytotoxic T-lymphocyte antigen 4 (CTLA4)-Ig at an intermediate culture phase. JTA-009 acts as a blocking antibody in vivo and inhibited binding of human AILIM/ICOS to mouse AILIM/ICOS ligand (B7h). Treatment with JTA-009 significantly prolonged survival of mice， with reductions of human interferon-gamma levels in blood and number of human cells in spleens. CONCLUSION： These results demonstrate that human AILIM/ICOS plays a role in the GVHD pathogenesis mediated by human T cells， and its blockade is attractive for abrogating undesired T-cell responses as is well-documented in mice.
(JTA) -- Several Arab countries banned the release of the film "Exodus： Gods and Kings."
PARIS (JTA) -- Anti-Israel protesters hurled a firebomb at a synagogue during an unauthorized demonstration in a heavily Jewish suburb of Paris.
(JTA) -- A Lebanese man who was arrested in Thailand on suspicion of belonging to Hezbollah admitted to targeting Israelis， Thai media reported.
JERUSALEM (JTA) -- Several public buses featuring photos of young women wearing kippot and prayer shawls were vandalized in Jerusalem.
(JTA) -- Anish Kapoor， a British Jewish artist， was knighted by Queen Elizabeth II.